Annexin A6

Annexin A6 (ANXA6) is a calcium-binding protein with a molecular mass of approximately 76 kDa that may associate with CD21 and regulate the release of calcium from intracellular stores (UniProt: P08133). The protein functions as a modulator of intracellular signaling, suggesting roles in cellular communication and membrane-related processes.

While no specific disease associations are documented in UniProt, Annexin A6 has been identified as relevant to Alzheimer's Disease pathology. In human post-mortem AD brain tissue compared to age-matched controls, Annexin A6 was consistently upregulated across subcellular fractions (mean log2 fold-change: 1.129) as detected by TMT-labeled tandem mass spectrometry across four fractionation steps (Chaparral AD proteomics). This upregulation suggests a potential role in AD-associated cellular stress responses or calcium dysregulation, key pathogenic mechanisms in neurodegeneration.