Thy-1 membrane glycoprotein

Thy-1 membrane glycoprotein (THY1) is a small glycosylated cell surface protein that may facilitate cell-cell or cell-ligand interactions during synaptogenesis and related neurobiological events in the brain (UniProt: P04216). The protein's role in synaptic development and plasticity positions it within neural circuitry formation pathways. No disease associations are documented in the UniProt record.

THY1 shows reduced expression in Alzheimer's Disease brain tissue. Chaparral AD proteomics analysis of post-mortem AD brain compared to age-matched controls identified THY1 as downregulated across synaptosomal fractions (mean log2FC: −0.75), detected in 2 of 4 subcellular fractions examined via TMT-labeled DDA proteomics. The decreased abundance of this synapse-associated protein is consistent with synaptic pathology and loss observed in AD neurodegeneration.