protein
Apolipoprotein A-II
aka Apo-AII, ApoA-II
Gene
APOA2
Organism
Homo sapiens(9606)
Length
100 aa
Mass
11,175 Da
Apolipoprotein A-II (APOA2) is a 100-amino acid protein that plays a structural role in high-density lipoprotein (HDL) metabolism by stabilizing HDL particles through lipid association (UniProt: P02652). The protein is involved in lipid transport and metabolism pathways, with no documented Mendelian disease associations in UniProt.
APOA2 is relevant to Alzheimer's Disease pathology. Proteomics analysis of post-mortem AD brain tissue versus age-matched controls revealed significant downregulation of APOA2, with a mean log2 fold-change of −1.1 across subcellular fractions (Chaparral AD proteomics). This downregulation suggests impaired HDL-mediated lipid metabolism in AD brain, which may contribute to the neuroinflammatory and metabolic dysfunction characteristic of the disease. The consistent reduction across multiple subcellular compartments indicates a global decrease in APOA2 protein levels in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
not detected
S3
-1.105
Mean log₂FC across detected fractions: -1.1047 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism
Sources
Last updated 5/8/2026, 6:31:26 AM