protein
V-type proton ATPase subunit G 2
aka V-ATPase subunit G 2
Gene
ATP6V1G2
Organism
Homo sapiens(9606)
Length
118 aa
Mass
13,604 Da
ATP6V1G2 encodes V-type proton ATPase subunit G 2, a component of the V1 complex of vacuolar H+-ATPase (V-ATPase). This multisubunit enzyme hydrolyzes ATP to transport protons across membranes, thereby acidifying intracellular compartments and, in some cell types, the extracellular environment (UniProt: O95670).
V-ATPase subunit G 2 functions in pH regulation within endosomal, lysosomal, and other acidic cellular compartments. These organelles are critical for protein degradation, autophagy, and cellular homeostasis—processes fundamental to neuronal health. The protein is expressed broadly across tissues and has no documented Mendelian disease associations in UniProt.
In Alzheimer's disease, ATP6V1G2 is significantly downregulated in post-mortem brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.49 across subcellular fractions (Chaparral AD proteomics). This reduction may impair lysosomal and endosomal acidification, potentially compromising autophagic clearance of amyloid-β and tau aggregates—hallmark pathologies in AD pathogenesis.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.644
P2
-0.327
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.4856 (2 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment
Sources
Last updated 5/8/2026, 6:26:33 AM