Arf-GAP domain and FG repeat-containing protein 2

AGFG2 encodes Arf-GAP domain and FG repeat-containing protein 2, a 481-amino acid protein of 48.96 kDa (UniProt: O95081). The protein contains an ADP-ribosylation factor GTPase-activating protein (Arf-GAP) domain and FG repeats, suggesting roles in vesicular trafficking and protein–protein interactions; however, detailed functional annotation is limited in the current UniProt record.

AGFG2 has not been assigned to a specific tissue or pathway in curated disease databases. No disease associations are listed in the UniProt record for this accession.

AGFG2 is tagged as having relevance to Alzheimer's Disease with an ambiguous direction of change. In human post-mortem AD brain tissue compared to age-matched controls, AGFG2 showed a mean log2 fold-change of +0.145 across two subcellular fractions from TMT-labeled quantitative proteomics (Chaparral AD proteomics). This modest, near-neutral shift suggests minimal or inconsistent dysregulation of AGFG2 in AD-affected brain tissue, with expression changes likely differing by subcellular compartment.