protein
Cytosolic 10-formyltetrahydrofolate dehydrogenase
aka 10-FTHFDH, FDH
Gene
ALDH1L1
Organism
Homo sapiens(9606)
Length
902 aa
Mass
98,829 Da
ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is an NADP(+)-dependent enzyme that catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide, functioning in one-carbon metabolism (UniProt: O75891). The protein may also possess aldehyde dehydrogenase activity toward formaldehyde and other aldehydes. It is expressed as a 902-amino-acid cytosolic protein in humans.
ALDH1L1 participates in folate-dependent metabolic pathways critical for nucleotide synthesis and methylation reactions. No baseline disease associations are documented in UniProt for this protein.
ALDH1L1 is upregulated in Alzheimer's disease brain tissue. Post-mortem analysis of AD brain versus age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions (P2, P3, S2, S3) showed a mean log2 fold-change of +0.96, indicating elevated protein abundance in the disease state (Chaparral AD proteomics). This upregulation may reflect altered one-carbon metabolism or detoxification responses associated with AD neuropathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+1.691
P2
+0.679
S2
not detected
S3
+0.523
Mean log₂FC across detected fractions: +0.9642 (3 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity)
Sources
Last updated 5/8/2026, 6:34:32 AM