protein
Arf-GAP with dual PH domain-containing protein 1
Gene
ADAP1
Organism
Homo sapiens(9606)
Length
374 aa
Mass
43,395 Da
ADAP1 (Arf-GAP with dual PH domain-containing protein 1) is a GTPase-activating protein for ADP ribosylation factors that regulates intracellular membrane trafficking and vesicle biogenesis. It binds phosphatidylinositol lipids and controls the incorporation of tetraspanins CD63 and CD9 into multivesicular bodies (UniProt: O75689).
The protein is involved in endosomal-lysosomal pathway regulation, processes central to protein homeostasis and cellular waste clearance. UniProt records no annotated disease associations for ADAP1.
In Alzheimer's disease, ADAP1 is significantly downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −1.13 across subcellular fractions (Chaparral AD proteomics). This reduction may impair multivesicular body biogenesis and endosomal trafficking, potentially contributing to the accumulation of pathogenic protein aggregates characteristic of AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-1.127
S3
not detected
Mean log₂FC across detected fractions: -1.1266 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696)
Sources
Last updated 5/8/2026, 6:36:59 AM