protein
Adhesion G protein-coupled receptor B2
Gene
ADGRB2
Organism
Homo sapiens(9606)
Length
1585 aa
Mass
172,656 Da
Adhesion G protein-coupled receptor B2 (ADGRB2) is an orphan G-protein coupled receptor that mediates cell adhesion and cell-cell interactions (UniProt: O60241). The protein activates NFAT-signaling pathway through the G-protein GNAZ and is implicated in angiogenesis inhibition.
ADGRB2 is expressed across tissues with roles in adhesion-related signaling. No intrinsic disease associations are documented in UniProt curated records.
In Alzheimer's Disease, ADGRB2 shows significant downregulation in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: −0.44; Chaparral AD proteomics). The protein was quantified across subcellular fractions in a TMT-labeled differential proteomics study. This reduced expression may reflect altered cell adhesion signaling or impaired angiogenic processes in AD pathology, though the functional consequences remain to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.442
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.4422 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity)
Sources
Last updated 5/8/2026, 6:36:45 AM