protein
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Gene
ASAP2
Organism
Homo sapiens(9606)
Length
1006 aa
Mass
111,651 Da
ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2) is a GTPase-activating protein that activates the small GTPases ARF1, ARF5, and ARF6 (UniProt: O43150). It regulates post-Golgi vesicle formation and constitutive secretion, while also modulating Fc gamma receptor-mediated phagocytosis and cell migration through PXN recruitment to focal contacts.
ASAP2 is broadly expressed across tissues and participates in vesicular trafficking and cytoskeletal remodeling pathways. UniProt records no primary disease associations for this protein.
In Alzheimer's Disease, ASAP2 is downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −1.255 in human post-mortem AD brain across TMT-labeled subcellular fractions using DDA proteomics. This reduction may reflect altered protein trafficking or vesicle dynamics in the AD pathological context, though the functional consequence of ASAP2 downregulation in neurodegeneration remains to be established.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-1.255
S3
not detected
Mean log₂FC across detected fractions: -1.255 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration
Sources
Last updated 5/8/2026, 6:29:20 AM