Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2) is a GTPase-activating protein that activates the small GTPases ARF1, ARF5, and ARF6 (UniProt: O43150). It regulates post-Golgi vesicle formation and constitutive secretion, while also modulating Fc gamma receptor-mediated phagocytosis and cell migration through PXN recruitment to focal contacts.

ASAP2 is broadly expressed across tissues and participates in vesicular trafficking and cytoskeletal remodeling pathways. UniProt records no primary disease associations for this protein.

In Alzheimer's Disease, ASAP2 is downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −1.255 in human post-mortem AD brain across TMT-labeled subcellular fractions using DDA proteomics. This reduction may reflect altered protein trafficking or vesicle dynamics in the AD pathological context, though the functional consequence of ASAP2 downregulation in neurodegeneration remains to be established.