Protein phosphatase 1G

Protein phosphatase 1G (PPM1G) is a serine/threonine phosphatase that regulates protein dephosphorylation in cellular signaling pathways (UniProt: O15355). The enzyme belongs to the PP2C family of metal-dependent phosphatases and is expressed across multiple tissues, where it modulates signal transduction through removal of phosphate groups from target proteins.

PPM1G functions in cellular stress responses and metabolic regulation. No specific tissue localization or established disease associations are documented in UniProt for this protein.

PPM1G shows decreased abundance in Alzheimer's disease brain tissue. Analysis of post-mortem AD brain samples compared to age-matched controls revealed downregulation with a mean log2 fold-change of −0.852 across subcellular fractions using TMT-labeled quantitative proteomics (Chaparral AD proteomics). This reduction may reflect altered phosphatase-mediated signaling in AD pathology, though the functional significance of PPM1G loss in neurodegeneration requires further investigation.