Isoform 6 of Disks large-associated protein 1

DLGAP1 isoform 6, also known as disks large-associated protein 1 (DAP-1), is a 685-amino acid scaffolding protein encoded by the DLGAP1 gene (UniProt: O14490-6). Scaffolding proteins of this family typically organize signaling complexes at synaptic junctions, though specific functional annotations are not detailed in current curated records.

DLGAP1 is expressed in nervous tissue and plays roles in synaptic architecture and organization. The protein has been implicated in neurodevelopmental and neurological processes through its interactions with postsynaptic density components, though no explicit disease associations are documented in the UniProt entry for this isoform.

This isoform is tagged as downregulated in Alzheimer's disease. In post-mortem AD brain tissue compared to age-matched controls, DLGAP1 isoform 6 showed reduced abundance with a mean log2 fold-change of −0.49 (Chaparral AD proteomics; human post-mortem AD brain vs age-matched controls, TMT-labeled quantification across subcellular fractions). The modest magnitude of change across the measured fraction(s) suggests potential selective loss in particular cellular compartments relevant to synaptic dysfunction in AD pathology.