Soluble lamin-associated protein of 75 kDa

Soluble lamin-associated protein of 75 kDa (SLAP75), encoded by FAM169A, is a 670-amino-acid protein of approximately 75 kDa molecular weight (UniProt: Q9Y6X4). Its specific molecular and cellular functions are not currently annotated in UniProt.

The protein's tissue distribution and biological pathways have not been characterized in available databases. No primary disease associations are documented in the UniProt record.

FAM169A is associated with Alzheimer's Disease: analysis of post-mortem AD brain tissue versus age-matched controls using tandem mass tag proteomics across four subcellular fractions revealed upregulation of this protein in AD brain (Chaparral AD proteomics). The mean log2 fold-change was 0.7949, indicating moderate elevation across the examined fractions.