Dual specificity tyrosine-phosphorylation-regulated kinase 1B

DYRK1B (dual specificity tyrosine-phosphorylation-regulated kinase 1B) is a serine/threonine and tyrosine kinase involved in ribosomal DNA double-strand break repair and rDNA copy number maintenance. It also regulates transcription through phosphorylation of histone methyltransferases, modulates signaling pathways including TCF1/HNF1A and FOXO1, and influences metabolic processes such as adipogenesis and gluconeogenesis (UniProt: Q9Y463).

The protein is implicated in metabolic homeostasis and cellular stress responses. UniProt associates DYRK1B variants with abdominal obesity-metabolic syndrome 3 (AOMS3; MIM 615812), characterized by central obesity, hypertension, and early-onset cardiovascular disease.

DYRK1B shows reduced expression in Alzheimer's disease brain tissue. In post-mortem AD brain compared to age-matched controls, DYRK1B was significantly downregulated with a mean log2 fold-change of −0.40 across subcellular fractions analyzed by TMT-labeled proteomics (Chaparral AD proteomics). This downregulation may relate to impaired DNA damage responses or metabolic dysregulation observed in AD pathology.