Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

PPP2R2C encodes the 55 kDa B regulatory subunit gamma isoform of serine/threonine protein phosphatase 2A (PP2A). This regulatory subunit is thought to modulate substrate selectivity and catalytic activity of the PP2A holoenzyme and direct the enzyme's localization to specific subcellular compartments (UniProt: Q9Y2T4).

PP2A complexes are implicated in phosphoregulation of numerous cellular processes across neuronal and non-neuronal tissues. No disease associations are documented in UniProt for this isoform.

PPP2R2C shows reduced expression in Alzheimer's disease brain. Chaparral AD proteomics analysis of human post-mortem AD brain versus age-matched controls (TMT-labeled DDA across four subcellular fractions: P2, P3, S2, S3) demonstrates significant downregulation with a mean log2 fold-change of −0.72 (Chaparral AD proteomics). This decrease may reflect altered PP2A-mediated phosphatase signaling in AD pathology.