Band 4.1-like protein 3

EPB41L3 encodes Band 4.1-like protein 3, a 1,087-amino acid tumor suppressor that inhibits cell proliferation and promotes apoptosis (UniProt: Q9Y2J2). The protein modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5, which are involved in post-translational modification and protein regulatory functions.

EPB41L3 is primarily characterized through its tumor-suppressive roles, though specific tissue-localization details and canonical signaling pathways are not extensively annotated in the UniProt record (UniProt: Q9Y2J2). No primary disease associations are documented in UniProt's disease field.

In Alzheimer's Disease, EPB41L3 shows significant downregulation in human post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Quantitative proteomics analysis via TMT-labeled mass spectrometry across four subcellular fractions (P2, P3, S2, S3) revealed a mean log2 fold-change of −0.685, indicating reduced protein abundance in the AD brain. The functional consequences of this downregulation in neurodegeneration warrant further investigation.