RuvB-like 2 (RUVBL2) Summary

RUVBL2 is a DNA helicase and ATPase component of multiple chromatin-remodeling complexes, including NuA4, SWR1-like, and INO80 complexes (UniProt: Q9Y230). It catalyzes ATP-dependent DNA unwinding and nucleosome remodeling, and contributes to histone acetylation-mediated transcriptional activation. The protein also participates in DNA repair, endoplasmic reticulum-associated degradation, and modulation of oncogenic transcription programs.

RUVBL2 is widely expressed and functions in nuclear processes central to chromatin homeostasis and gene regulation (UniProt: Q9Y230). No intrinsic disease annotations are documented in UniProt for this protein.

In Alzheimer's Disease, RUVBL2 shows ambiguous regulation across subcellular fractions in post-mortem AD brain tissue versus age-matched controls by quantitative proteomics (Chaparral AD proteomics). The mean log2 fold-change is 0.30, indicating modest overall elevation, though direction varies by subcellular compartment (mean log2FC: 0.3019 across 2 fractions). This suggests compartment-specific changes in RUVBL2 abundance in AD pathology.