Stomatin-like protein 2, mitochondrial

STOML2 (stomatin-like protein 2, mitochondrial; also known as SLP-2) is a 356-amino-acid mitochondrial protein that regulates mitochondrial biogenesis and function (UniProt: Q9UJZ1). It stimulates cardiolipin biosynthesis and stabilizes mitochondrial membrane proteins including prohibitin, thereby organizing functional microdomains within mitochondrial membranes. The protein influences diverse cellular processes including cell migration, proliferation, T-cell activation, calcium homeostasis, and stress response, and is required for mitochondrial hyperfusion—a pro-survival response that increases ATP production during cellular stress.

STOML2 is expressed primarily in mitochondria but also participates in plasma membrane organization and T-cell receptor signaling. No disease associations are documented in UniProt curated entries. However, quantitative proteomics profiling of post-mortem Alzheimer's disease brain tissue (TMT-labeled DDA analysis across four subcellular fractions) revealed upregulation of STOML2 in AD cases relative to age-matched controls (mean log2 fold-change: 1.541; Chaparral AD proteomics). This elevation suggests a potential compensatory or pathological response involving mitochondrial dysfunction in AD pathology, though functional significance remains to be determined.