Exportin-7

Exportin-7 (XPO7) is a nuclear export receptor that mediates the transport of protein cargos from the nucleus to the cytoplasm with broad substrate specificity (UniProt: Q9UIA9). The protein functions as part of a trimeric complex with Ran-GTP and its cargo, docking to the nuclear pore complex and facilitating cargo release upon cytoplasmic entry through Ran-GTP hydrolysis. This nucleocytoplasmic transport mechanism is fundamental to cellular regulation across diverse tissues.

XPO7 is expressed as a 1,087 amino acid protein and has no annotated disease associations in UniProt. The protein's role in nuclear transport connects it broadly to cellular homeostasis and protein localization pathways essential for normal cellular function.

In Alzheimer's Disease, XPO7 shows ambiguous regulation across subcellular fractions in post-mortem human brain tissue (Chaparral AD proteomics). The overall mean log2 fold-change is −0.1758 relative to age-matched controls, but this direction varies across the two fractions detected (ad:direction:ambiguous), making interpretation of consistent up- or down-regulation unclear. Further investigation into XPO7's role in AD-related protein trafficking or neurodegeneration would be warranted.