Cytochrome b-c1 complex subunit 9

Cytochrome b-c1 complex subunit 9 (UQCR10) is a 63-amino acid component of the ubiquinol-cytochrome c oxidoreductase complex, a critical element of the mitochondrial electron transport chain (UniProt: Q9UDW1). It catalyzes electron transfer from ubiquinol to cytochrome c while coupling this redox reaction to proton translocation across the inner mitochondrial membrane, thereby supporting oxidative phosphorylation and ATP synthesis.

UQCR10 is an integral membrane protein of complex III in the mitochondrial respiratory chain, participating in the Q cycle and energy coupling mechanisms essential for neuronal metabolism. UniProt records no primary disease associations for this protein.

UQCR10 shows Alzheimer's Disease relevance based on proteomic evidence in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein is significantly upregulated (mean log2FC = 1.09) in AD brain, suggesting altered mitochondrial energy metabolism in Alzheimer's pathology.