GMP reductase 2

GMP reductase 2 (GMPR2) is a nucleotide-metabolizing enzyme that catalyzes the NADPH-dependent deamination of GMP to IMP (UniProt: Q9P2T1). This enzymatic activity functions in converting guanine-derived nucleotides to adenine-derived nucleotides and maintaining the intracellular balance of purine nucleotides. Beyond nucleotide metabolism, GMPR2 has been implicated in modulating cellular differentiation.

GMPR2 is expressed in human tissues and participates in nucleotide homeostasis pathways central to cellular energy metabolism and nucleic acid synthesis. No specific disease associations are documented in UniProt for this protein.

In Alzheimer's Disease, GMPR2 shows increased abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein is significantly upregulated with a mean log2 fold-change of 0.41, suggesting elevated nucleotide catabolism or altered purine metabolism may accompany AD pathology. This upregulation was detected in human post-mortem brain tissue by TMT-labeled quantitative proteomics across multiple subcellular fractions.