Serine-rich coiled-coil domain-containing protein 2

CCSER2 (serine-rich coiled-coil domain-containing protein 2) is a microtubule-binding protein with a putative role in microtubule bundling (UniProt: Q9H7U1). The protein is 834 amino acids in length and expressed in human tissues.

CCSER2 is involved in cytoskeletal organization through its interaction with microtubules. No disease associations are documented in UniProt records for this protein.

CCSER2 shows downregulation in Alzheimer's Disease brain. Quantitative proteomics analysis of post-mortem AD brain tissue versus age-matched controls detected CCSER2 across one subcellular fraction with a mean log2 fold-change of −0.52 (Chaparral AD proteomics). This modest downregulation suggests potential involvement in AD-related cytoskeletal dysfunction, though the biological significance requires further investigation.