(E3-independent) E2 ubiquitin-conjugating enzyme

UBE2O is an E2/E3 hybrid ubiquitin-conjugating enzyme that catalyzes monoubiquitination of target proteins and possesses both E2 and E3 ligase activities (UniProt: Q9C0C9). The protein regulates multiple cellular processes including NF-κB signaling, BMP7-mediated adipogenesis, subcellular protein localization via nuclear localization signal modification, and retrograde endosomal transport through WASHC1 ubiquitination.

UBE2O is widely expressed across tissues and participates in diverse signaling pathways through its role as a ubiquitin ligase (UniProt: Q9C0C9). Its functions span chromatin-associated protein regulation and immune signaling modulation, indicating broad cellular relevance.

UBE2O is downregulated in Alzheimer's disease brain tissue. Quantitative proteomics from post-mortem AD brain compared to age-matched controls revealed a mean log2 fold-change of −0.64 (Chaparral AD proteomics). This downregulation suggests potential involvement in AD-relevant pathways, though the direction and functional consequence warrant further investigation.