Nucleosome assembly protein 1-like 4

NAP1L4 (nucleosome assembly protein 1-like 4) is a histone chaperone that facilitates nucleosome assembly and chromatin remodeling (UniProt: Q99733). The protein plays a role in regulating chromatin structure and gene expression through its interaction with histones during nucleosome formation.

NAP1L4 is expressed broadly across human tissues and is involved in fundamental processes of chromatin dynamics. No specific tissue-restricted expression pattern or canonical disease associations are documented in UniProt for this protein.

This protein has been identified as relevant to Alzheimer's Disease through proteomic analysis of post-mortem AD brain tissue. Quantitative proteomics data from TMT-labeled subcellular fractionation (P2, P3, S2, S3 fractions) show an ambiguous direction of change with a mean log2 fold-change of 0.167 relative to age-matched controls (Chaparral AD proteomics). The modest fold-change and variable direction across fractions suggest potential but subtle involvement in AD-related pathology, though the biological significance requires further investigation.