Erbin

Erbin (ERBIN) is a 1412-amino acid adapter protein that functions as a regulator of the ERBB2 receptor in epithelial tissues (UniProt: Q96RT1). It stabilizes the unphosphorylated state of ERBB2's Tyr-1248 residue and inhibits NOD2-dependent NF-κB signaling and pro-inflammatory cytokine secretion, suggesting roles in receptor homeostasis and innate immune regulation.

While Erbin lacks curated disease associations in UniProt, it has been identified in Alzheimer's Disease research contexts. Analysis of post-mortem AD brain tissue versus age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions revealed Erbin is upregulated in AD (Chaparral AD proteomics). The mean log2 fold-change is 0.3161, indicating modest elevation in the disease state.

The functional significance of Erbin elevation in AD brain warrants further investigation, particularly regarding its potential contribution to neuroinflammatory processes through NOD2-NF-κB pathway modulation and its interactions with ERBB2 signaling in neuronal contexts.