Leucine rich adaptor protein 1

Leucine rich adaptor protein 1 (LURAP1) is a 239-amino acid adaptor protein encoded by the LURAP1 gene (UniProt: Q96LR2). It functions as an activator of the canonical NF-κB pathway and promotes pro-inflammatory cytokine production. LURAP1 also coordinates with myosin and Rho-family GTPases to regulate actomyosin dynamics and cell migration through lamellar retrograde flow and phosphorylation of regulatory light chains.

LURAP1 is implicated in immune cell function, particularly in dendritic cell antigen presentation and priming via NF-κB signaling (UniProt: Q96LR2). Its role in actomyosin organization connects it to cellular processes essential for migration and morphogenesis.

This protein is associated with Alzheimer's Disease and is downregulated in AD pathology. Analysis of post-mortem AD brain tissue versus age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions revealed decreased LURAP1 abundance, with a mean log2 fold-change of −0.484 (Chaparral AD proteomics). The functional significance of LURAP1 reduction in AD neuropathology remains to be determined, though diminished NF-κB signaling capacity could impact neuroinflammatory responses.