EVI5-like protein

EVI5L (EVI5-like protein) is a 794-amino acid protein that functions as a broad-specificity GTPase-activating protein (GAP), regulating small GTPase signaling pathways (UniProt: Q96CN4). GTPase-activating proteins modulate GTP hydrolysis and thereby control the activity state of Ras-family and Rho-family GTPases, which are critical for cellular signaling, cytoskeletal dynamics, and vesicular trafficking.

The protein shows no documented disease associations in UniProt, and tissue-specific expression details are not available in the current record. However, the broad functions of GAPs suggest potential roles in synaptic regulation and neuronal signaling processes.

EVI5L is implicated in Alzheimer's Disease based on quantitative proteomics analysis. In human post-mortem AD brain tissue compared to age-matched controls, EVI5L is significantly down-regulated (mean log2 fold-change: −0.5713; Chaparral AD proteomics). This down-regulation was detected across the measured subcellular fractions in a TMT-labeled, data-dependent acquisition proteomics study, suggesting reduced GAP activity as a potential contributor to dysregulated GTPase signaling in AD pathology.