Isoform 2 of Probable ATP-dependent RNA helicase DDX17

DDX17 (DEAD-box helicase 17) is an ATP-dependent RNA helicase encoded by the DDX17 gene (UniProt: Q92841-1). The protein belongs to the DEAD-box family of helicases and is involved in RNA processing, including roles in pre-mRNA splicing and RNA remodeling. The mature protein is approximately 72 kDa in mass.

DDX17 is broadly expressed across human tissues and participates in fundamental RNA metabolism pathways. While UniProt records no specific curated disease associations, the protein has been subject to proteomic investigation in neurological contexts.

In Alzheimer's Disease, DDX17 shows significant upregulation in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics; mean log2 fold-change: +0.58, direction: up). This increase was detected via TMT-labeled quantitative proteomics across four subcellular fractions from affected brain tissue. The upregulation of RNA helicases in AD brain may reflect compensatory responses to RNA dysmetabolism or proteostatic stress characteristic of the disease pathology.