Charged multivesicular body protein 7

CHMP7 (Charged multivesicular body protein 7) is an ESCRT-III-like protein that functions as a critical recruiter of the ESCRT-III complex to the nuclear envelope during late anaphase (UniProt: Q8WUX9). Working alongside SPAST, it promotes nuclear envelope sealing and mitotic spindle disassembly. The protein is also recruited to the reforming nuclear envelope during anaphase by LEMD2 and participates in endosomal sorting pathways.

CHMP7 is expressed in human tissues and its normal functions center on nuclear envelope dynamics and membrane trafficking processes (UniProt: Q8WUX9). No baseline disease associations are documented in UniProt.

CHMP7 shows elevated expression in Alzheimer's Disease brain tissue. In post-mortem AD brain tissue compared to age-matched controls, CHMP7 was upregulated with a mean log2 fold-change of 0.65 across one subcellular fraction in TMT-labeled quantitative proteomics (Chaparral AD proteomics). This upregulation may reflect altered nuclear envelope integrity or membrane trafficking dysfunction in AD pathology.