RB1-inducible coiled-coil protein 1

RB1-inducible coiled-coil protein 1 (RB1CC1) is a multifunctional protein involved in autophagy, DNA damage repair, and transcriptional regulation (UniProt: Q8TDY2). It regulates both early and late autophagosome formation through interaction with Atg16L1, inhibits focal adhesion kinase signaling, modulates TGF-beta pathway specificity, and plays a role in inducing RB1 expression. The protein also participates in muscular differentiation and neuronal homeostasis regulation.

RB1CC1 is expressed across multiple tissues and functions in fundamental cellular processes including xenophagy and ionizing radiation-induced DNA damage responses. UniProt records no primary disease associations, though its roles in autophagy and neuronal homeostasis suggest potential relevance to neurodegenerative contexts.

In Alzheimer's disease, RB1CC1 is significantly downregulated in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: −0.3346; Chaparral AD proteomics). This downregulation was observed across the analyzed subcellular fractions in a TMT-labeled proteomics study, suggesting potential impairment of autophagy-related mechanisms in AD pathology.