SPRY domain-containing protein 3

SPRYD3 (SPRY domain-containing protein 3) is a 442-amino-acid protein encoded by the SPRYD3 gene in humans (UniProt: Q8NCJ5). The protein contains a SPRY domain, a conserved motif found in signaling and regulatory proteins, though its specific molecular function has not been detailed in current UniProt annotations.

Limited information is available regarding SPRYD3's tissue distribution and pathway context from curated databases. No disease associations are documented in UniProt's disease section for this protein.

SPRYD3 shows potential relevance to Alzheimer's Disease based on proteomic analysis. In human post-mortem AD brain tissue compared to age-matched controls, SPRYD3 was downregulated with a mean log2 fold-change of −0.60 across subcellular fractions in TMT-labeled tandem mass spectrometry analysis (Chaparral AD proteomics). This consistent downregulation may suggest altered expression in AD neuropathology, though the biological significance of this change remains to be determined.