Glutamine amidotransferase-like class 1 domain-containing protein 1

GATD1 (glutamine amidotransferase-like class 1 domain-containing protein 1) is a 220-amino acid protein that functions as a component of the FERRY complex, a five-subunit endosomal complex involved in mRNA localization and distribution (UniProt: Q8NB37). The FERRY complex acts as a RAB5A effector that mediates endosomal transport by directly interacting with mRNAs and ribosomes, thereby recruiting them to early endosomes.

GATD1 is primarily implicated in intracellular mRNA trafficking and endosomal biology. No disease associations are documented in UniProt, though the protein's role in cellular transport may have broader relevance to neurodegenerative processes affecting membrane trafficking.

GATD1 is associated with Alzheimer's Disease in this dataset, though with ambiguous direction of change (Chaparral AD proteomics). Analysis of post-mortem AD brain tissue versus age-matched controls using TMT-labeled proteomics across four subcellular fractions yielded a mean log2 fold-change of −0.12, indicating minimal and inconsistent regulation across fractions. The modest magnitude and directional ambiguity suggest GATD1 is not a primary driver of AD pathology, though subcellular redistribution cannot be excluded.