LRRC47 Summary

LRRC47 (leucine-rich repeat-containing protein 47) is a 583-amino acid protein encoded by the LRRC47 gene in humans (UniProt: Q8N1G4). The protein's specific molecular functions are not documented in current UniProt records, though its leucine-rich repeat domain suggests potential roles in protein–protein interactions.

Tissue localization and broader pathway context for LRRC47 are not annotated in UniProt, and no primary disease associations are listed in the curated database.

LRRC47 shows reduced abundance in Alzheimer's disease pathology. In human post-mortem AD brain tissue compared to age-matched controls, LRRC47 is downregulated (mean log2 fold-change: −1.01; Chaparral AD proteomics). This downregulation was detected via tandem mass tag (TMT) proteomics across four subcellular fractions, indicating consistent loss of this protein in the AD brain. The functional consequence of LRRC47 reduction in neurodegeneration remains unclear and warrants further investigation.