Threonine synthase-like 1

Threonine synthase-like 1 (THNSL1, also known as TSH1) is a 743-amino-acid protein of unknown enzymatic function in humans (UniProt: Q8IYQ7). Despite its name similarity to threonine synthase, its precise molecular role remains to be elucidated.

THNSL1 is a human protein with no annotated UniProt disease associations or established tissue-specific expression pattern in the provided record. Its cellular and pathway context have not been systematically characterized in curated databases.

THNSL1 is associated with Alzheimer's disease based on proteomics evidence. The protein is consistently downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.458 (Chaparral AD proteomics). This reduction was detected across human brain subcellular fractions in a tandem mass tag (TMT) labeling experiment, suggesting potential involvement in AD-associated neuronal pathology, though the functional significance of this downregulation remains unclear.