Hydroxysteroid dehydrogenase-like protein 2

HSDL2 (hydroxysteroid dehydrogenase-like protein 2) is a 418-amino acid protein that lacks classical steroid dehydrogenase enzymatic activity but functions in bile acid and lipid metabolism in response to nutritional signals (UniProt: Q6YN16).

The protein is involved in hepatic and metabolic pathways governing bile acid processing and lipid homeostasis. UniProt records no established disease associations for HSDL2.

HSDL2 shows increased abundance in Alzheimer's disease brain tissue. Analysis of post-mortem AD brain compared to age-matched controls by quantitative proteomics (TMT-labeled, DDA approach across four subcellular fractions) detected HSDL2 as upregulated with a mean log2 fold-change of 0.36 (Chaparral AD proteomics). This modest elevation suggests potential involvement in metabolic dysregulation associated with AD pathology, though the biological significance of this change remains to be determined.