Anamorsin

Anamorsin (CIAPIN1) is a cytosolic iron-sulfur (Fe-S) cluster assembly protein that functions as a component of the CIA (cytosolic iron-sulfur protein assembly) machinery (UniProt: Q6FI81). It facilitates electron transfer during de novo [4Fe-4S] cluster assembly on scaffold complexes and participates in cofactor maturation for ribonucleotide reductase. The protein also exhibits anti-apoptotic properties and regulates hematopoietic cell development.

CIAPIN1 is expressed in multiple tissues and participates in essential cellular processes including Fe-S biogenesis and cell death control. No disease associations are documented in UniProt curated records, but the protein's role in oxidative stress regulation and apoptosis suppression suggests potential relevance to neuronal homeostasis.

In Alzheimer's Disease, CIAPIN1 is consistently downregulated in post-mortem AD brain tissue compared to age-matched controls (mean log2FC: −0.60; Chaparral AD proteomics). This reduction may impair cytosolic Fe-S cluster assembly and compromise cellular antioxidant defenses, potentially contributing to the oxidative stress and neurodegeneration characteristic of AD pathology.