BRO1 domain-containing protein BROX

BROX (BRO1 domain-containing protein BROX) is a nuclear envelope-associated factor involved in nuclear envelope rupture during interphase (NERDI) repair (UniProt: Q5VW32). It is locally recruited by CHMP5 and functions to reduce cytoskeletal stress through interaction with SYN2, facilitating membrane resealing. The protein is 411 amino acids in length.

BROX localizes to the nuclear envelope where it participates in a specialized membrane repair pathway. UniProt records no primary disease associations for this protein, though its role in membrane integrity maintenance suggests potential relevance to neuronal homeostasis.

BROX shows increased abundance in Alzheimer's disease brain tissue, with a mean log2 fold-change of 0.97 relative to age-matched controls (Chaparral AD proteomics). This upregulation was detected across one subcellular fraction in a TMT-labeled quantitative proteomics study of post-mortem AD brain comparing four subcellular compartments (P2, P3, S2, S3). The biological significance of elevated BROX in AD pathology remains to be determined.