Striatin-interacting protein 1

Striatin-interacting protein 1 (STRIP1) is a 95.6 kDa scaffolding protein encoded by STRIP1. It functions as a component of striatin-interacting phosphatase and kinase (STRIPAK) complexes, which regulate cytoskeletal organization, cell morphology, and actin filament dynamics (UniProt: Q5VSL9). STRIPAK complexes coordinate multiple signaling pathways including Hippo, MAPK, and nuclear receptor signaling, with roles in cell growth, differentiation, apoptosis, and metabolism.

STRIP1 is expressed in human brain and participates in cortical cytoskeletal remodeling. No explicit disease associations are documented in UniProt, though dysregulation of STRIPAK-mediated signaling could impact neuronal morphology and cellular homeostasis (UniProt: Q5VSL9).

In Alzheimer's disease, STRIP1 shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein was downregulated with a mean log2 fold-change of −0.39 across analyzed subcellular fractions in TMT-labeled quantitative proteomics. This downregulation may reflect altered cytoskeletal dynamics or signaling pathway dysregulation associated with AD pathology.