Coiled-coil domain-containing protein 93

CCDC93 is a coiled-coil domain-containing protein that functions as a component of the commander complex, which regulates endosomal recycling of transmembrane cargos (UniProt: Q567U6). Within the CCC subcomplex, CCDC93 associates with SNX17, retriever, and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of integrins, signaling receptors, and ion channels. It also participates in copper-dependent ATP7A trafficking between the trans-Golgi network and peripheral vesicles.

CCDC93 is involved in multiple cellular trafficking and recycling pathways critical for surface protein homeostasis. The protein has been implicated in human papillomavirus exit via its role in the commander complex, suggesting broader relevance to membrane transport mechanisms (UniProt: Q567U6).

In Alzheimer's Disease, CCDC93 shows down-regulation in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of human post-mortem AD brain tissue using TMT-labeled proteomics across four subcellular fractions yielded a mean log₂ fold-change of −0.811, indicating consistent reduction. This decreased expression may impair endosomal recycling capacity and cellular cargo trafficking in AD pathology.