Myeloid leukemia factor 2

Myeloid leukemia factor 2 (MLF2) is a 248-amino-acid protein encoded by the MLF2 gene in humans (UniProt: Q15773). Its specific molecular functions are not extensively characterized in the available UniProt record, though its name suggests potential involvement in myeloid cell biology and leukemia-related pathways.

MLF2 shows minimal annotation in UniProt regarding tissue distribution or established disease associations. The protein's expression pattern and biological role in normal physiology remain largely undefined in the current dataset.

MLF2 is relevant to Alzheimer's Disease research based on curated Chaparral tags. Proteomic analysis of post-mortem AD brain tissue versus age-matched controls detected MLF2 as downregulated (mean log2 fold-change: −0.56; Chaparral AD proteomics). This modest reduction was observed across a single subcellular fraction in TMT-labeled quantitative mass spectrometry. The functional significance of reduced MLF2 in AD pathology warrants further investigation.