Isoform LCRMP-4 of Dihydropyrimidinase-related protein 3

Dihydropyrimidinase-related protein 3 (DPYSL3), also known as DRP-3, is an isoform (LCRMP-4) of a collapsin response mediator protein family member involved in neurite outgrowth and axonal guidance (UniProt: Q14195-2). These proteins play conserved roles in neuronal cytoskeleton dynamics and are expressed across multiple brain regions and tissues.

DPYSL3 is part of the dihydropyrimidinase-related protein family, which functions in neuronal development and plasticity. The protein localizes to various subcellular compartments and participates in microtubule-associated processes essential for neuronal morphogenesis and synaptic function.

In Alzheimer's disease, DPYSL3/LCRMP-4 is significantly upregulated in post-mortem human brain tissue. Analysis of subcellular fractions (P2, P3, S2, S3) from AD brain versus age-matched controls revealed elevated protein levels with a mean log2 fold-change of +0.457 across fractions (Chaparral AD proteomics). This upregulation may reflect compensatory neuronal responses or altered axonal dynamics associated with neurodegeneration in AD pathology.