Heat shock protein 75 kDa, mitochondrial

TRAP1 (Heat shock protein 75 kDa, mitochondrial) is a mitochondrial chaperone with ATPase activity that maintains mitochondrial function and polarization downstream of PINK1 and mitochondrial complex I (UniProt: Q12931). It acts as a negative regulator of mitochondrial respiration, modulating the balance between oxidative phosphorylation and aerobic glycolysis, likely through effects on mitochondrial SRC and inhibition of SDHA (UniProt: Q12931).

TRAP1 is localized to mitochondria and plays a central role in cellular bioenergetics. No disease associations are listed in UniProt; however, its role in mitochondrial homeostasis implicates it in neurodegenerative processes.

TRAP1 is tagged for Alzheimer's Disease relevance. In post-mortem AD brain tissue analyzed by quantitative proteomics across subcellular fractions, TRAP1 shows ambiguous directional change with a mean log2 fold-change of −0.48 relative to age-matched controls (Chaparral AD proteomics). The inconsistent direction across fractions suggests complex compartmentalization or differential regulation depending on subcellular localization in AD pathology.