Lamin-B2

Lamin-B2 is an intermediate filament protein that forms a major structural component of the nuclear lamina, the fibrous layer underlying the inner nuclear membrane (UniProt: Q03252). It assembles into a filamentous meshwork that bridges the nuclear envelope and chromatin, providing essential scaffolding for nuclear assembly, chromatin organization, and nuclear envelope dynamics throughout the cell cycle.

Lamin-B2 is primarily expressed in nuclear structures and is implicated in several genetic disorders affecting neurodevelopment and metabolism, including progressive myoclonic epilepsy (EPM9), microcephaly (MCPH27), and partial acquired lipodystrophy (UniProt: Q03252). Its role in nuclear integrity and chromatin organization suggests broad relevance to cellular homeostasis.

In Alzheimer's disease, Lamin-B2 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The protein showed a mean log2 fold-change of +0.315 across subcellular fractions in TMT-labeled proteomics analysis, indicating elevated abundance in the AD brain. This upregulation may reflect changes in nuclear organization or cellular stress responses associated with neurodegeneration.