Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

GNG2 encodes guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, a 71-amino acid protein that functions as a modulator and transducer in transmembrane signaling systems (UniProt: P59768). The beta and gamma subunit chains are required for GTPase activity, GDP-to-GTP exchange, and G protein-effector interactions critical to cellular signal transduction (UniProt: P59768).

GNG2 is widely expressed across tissues and participates in G protein signaling cascades that regulate diverse physiological processes. UniProt records no curated disease associations in its primary annotation database.

In Alzheimer's Disease, GNG2 expression is significantly reduced in post-mortem AD brain tissue compared to age-matched controls. Chaparral AD proteomics data from human post-mortem AD brain analyzed by TMT-labeled DDA proteomics across four subcellular fractions show GNG2 is down-regulated with a mean log2 fold-change of −0.65 (Chaparral AD proteomics). This reduction may reflect impaired G protein signaling capacity in AD neuropathology.