Hepatoma-derived growth factor

Hepatoma-derived growth factor (HDGF) is a 240-amino acid protein with pleiotropic functions including transcriptional repression and mitogenic activity toward fibroblasts (UniProt: P51858). The protein exhibits heparin-binding capacity and is characterized by its growth factor signaling properties.

HDGF is broadly expressed across tissues and participates in cell proliferation and transcriptional regulation pathways. No specific disease associations are documented in the UniProt entry for this protein.

HDGF shows increased abundance in Alzheimer's disease brain tissue. According to Chaparral AD proteomics data from post-mortem AD brain versus age-matched controls (TMT-labeled quantification across four subcellular fractions), HDGF is upregulated with a mean log2 fold-change of 0.20. This modest but consistent elevation across the analyzed fractions suggests a potential role in AD-associated neurobiological changes, though the functional significance requires further investigation.