Protein phosphatase 1F

Protein phosphatase 1F (PPM1F) is a serine/threonine phosphatase that dephosphorylates and inactivates calcium/calmodulin-dependent kinases, including CaMKII, CaMKIV, and CaMKI (UniProt: P49593). The enzyme promotes apoptosis through its dephosphorylation activity and functions in calcium signaling pathways. PPM1F is a 454-amino-acid protein with a molecular mass of approximately 50 kDa.

No primary tissue localization is specified in UniProt, though the protein's role in CaMK regulation suggests involvement in calcium-responsive signaling. UniProt reports no curated disease associations in its annotation database, indicating PPM1F has not been linked to documented genetic diseases.

PPM1F is upregulated in Alzheimer's Disease brain tissue (Chaparral AD proteomics). Quantitative proteomics comparing post-mortem AD brain to age-matched controls detected PPM1F with a mean log2 fold-change of +0.91 across one of four analyzed subcellular fractions (P2, P3, S2, S3), suggesting modest elevation in AD pathology. The functional relevance of increased PPM1F in AD neurodegeneration remains to be determined.