Rap1 GTPase-activating protein 1

RAP1GAP (Rap1 GTPase-activating protein 1) is a GTPase regulator that converts the Ras-related protein RAP-1A to its GDP-bound inactive state (UniProt: P47736). The 663-amino acid protein functions as a critical signaling modulator in cells.

RAP1GAP operates within the broader Ras-family GTPase signaling network, which regulates diverse cellular processes including proliferation, differentiation, and neuronal function. No specific tissue localization or additional disease associations are documented in UniProt for this protein.

RAP1GAP is associated with Alzheimer's Disease according to curated tags. Proteomic analysis of post-mortem AD brain tissue versus age-matched controls revealed downregulation of RAP1GAP, with a mean log2 fold-change of −0.33 across one subcellular fraction in a TMT-labeled DDA proteomics experiment spanning four fractions (Chaparral AD proteomics). This modest decrease suggests potential impairment of RAP1A regulation in the AD brain, though the functional consequence remains to be clarified.