Crk-like protein (CRKL)

CRKL is a 33.8 kDa adaptor protein that may mediate intracellular signal transduction (UniProt: P46109). It belongs to the Crk family of proteins, which are known for their roles in regulating cell adhesion, migration, and receptor signaling pathways through protein-protein interactions.

The protein's tissue distribution and specific biological contexts are not extensively documented in available sources. UniProt does not list established disease associations for CRKL in the primary disease section.

CRKL has been examined in Alzheimer's Disease proteomics using post-mortem human brain tissue compared to age-matched controls via TMT-labeled, data-dependent acquisition mass spectrometry across four subcellular fractions (Chaparral AD proteomics). The direction of change is ambiguous across fractions, with a mean log2 fold-change near zero (−0.0058), suggesting minimal or inconsistent regulation of CRKL in AD brain pathology.