Isoform IIb of Profilin-2

Profilin-2 (PFN2) is a small actin-binding protein that regulates actin dynamics and cytoskeletal organization. The protein functions in controlling polymerization of actin filaments and plays roles in cell motility, neurite outgrowth, and synaptic plasticity (UniProt: P35080-2).

Profilin-2 is widely expressed in neural tissues and is particularly relevant in neuronal axons and dendrites where it modulates cytoskeletal remodeling. The UniProt record does not list curated disease associations in its primary annotation (UniProt: P35080-2).

Isoform IIb of Profilin-2 is upregulated in Alzheimer's disease brain tissue. In human post-mortem AD brain compared to age-matched controls, this isoform showed increased abundance with a mean log2 fold-change of 0.68 across TMT-labeled subcellular fractions analyzed by data-dependent acquisition proteomics (Chaparral AD proteomics). The upregulation suggests a potential compensatory or pathogenic role in AD-associated cytoskeletal changes.