Peptidyl-prolyl cis-trans isomerase FKBP2

FKBP2 (peptidyl-prolyl cis-trans isomerase FKBP2) is a 142-amino acid protein belonging to the immunophilin family of peptidylprolyl isomerases. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, thereby accelerating protein folding (UniProt: P26885).

The protein is expressed in human tissues and participates in protein homeostasis and folding pathways. No disease associations are documented in the UniProt record for FKBP2.

FKBP2 is upregulated in Alzheimer's disease brain tissue. Quantitative proteomics analysis of post-mortem AD brain versus age-matched controls identified increased FKBP2 abundance with a mean log2 fold-change of +1.117 (Chaparral AD proteomics). This upregulation suggests a potential role in the protein misfolding and aggregation pathology characteristic of AD, though the functional significance requires further investigation.