Ezrin

Ezrin (EZR) is a membrane-cytoskeleton linker protein that mediates connections between major cytoskeletal structures and the plasma membrane (UniProt: P15311). It is essential for microvilli and membrane ruffle formation in epithelial cells and, together with PLEKHG6, supports normal macropinocytosis. The protein is 586 amino acids in length with a mass of approximately 69 kDa.

Ezrin is broadly expressed across tissues where dynamic membrane organization is required. No primary disease associations are documented in UniProt for this protein.

In Alzheimer's Disease, ezrin is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of +0.76 (Chaparral AD proteomics). This upregulation was detected via TMT-labeled proteomics across four subcellular fractions (P2, P3, S2, S3) from human post-mortem AD brain samples, suggesting a potential role in AD-associated cytoskeletal remodeling or membrane perturbations.